Protease Inhibitors and Phosphatase Inhibitors
Apexbio Technology LLC Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO), 1ml x 10
Equivalent to Sigma P8215, for use with fungal and yeast extracts to increase protein stability. Other sizes are available. Please inqury us for quote.
Abcam KU-60019, ATM kinase inhibitor, 200MG
MW 547.7 Da, Purity >98%. Potent, highly selective ATM kinase inhibitor (IC₅₀ = 6.3 nM). Inhibits migration and invasion of glioma cells. Shows similar target selectivity to KU-55933 (ab120637). Shows radiosensitizing effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam GM 6001, MMP inhibitor, 1MG
MW 388.5 Da, Purity >98%. Broad spectrum potent MMP inhibitor. Ki values are 0.4 (MMP-1), 0.5 (MMP-2), 27 (MMP-3), 0.1 (MMP-8), 0.2 (MMP-9), 13.4 (MMP-14) and 0.36 (MMP-26) nM. IC₅₀ value for MMP-7 is 3.7 nM. Pharmacologically active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SU-5402 (DMSO solution), VEGFR and FGFR inhibitor, 500UG-LQD
MW 296.32 Da, Purity >98%. Potent, selective VEGFR and FGFR inhibitor (IC₅₀ values are 0.02 (VEGFR2), 0.03 (FGFR1), 0.51 (PDGFRβ) and >100 μM (EGFR)). Attenuates integrin β4-induced differentiation of neural stem cells. Shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Echelon Biosciences Research Labs AS604850 (PI3-K gamma Inhibitor 2) 1 mg
5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione (AS604850) is an inhibitor of PI 3-K with an IC50 = 250 nM. AS604850 is selective for the -isoform (IC50: PI 3-K = 4.5 M, PI 3-K, PI 3-K > 20 M) and shows no notable activity against a wide array of protein kinases at 1 M.nn
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Solubility
nWater: insoluble, DMSO: 5 mg/mLnStorage
nStore dry between 2-8oC. Stock solutions should be stored frozen (-20oC).nReferences
n1) M. Camps et al. "Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis" Nature Medicine, 2005, 11, 936-943.nnnn
Documents
nTechnical Data Sheet This item is non returnable
Sigma Aldrich Fine Chemicals Biosciences Sodium phenylbutyrate, 1716-12-7, MFCD00800247, 100 mg
Empirical Formula (Hill Notation): C10H11NaO2, Molecular Weight: 186.18, ≥98% (HPLC), storage temp: room temp, Synonym: 4-PBA, 4-Phenylbutyric acid, 4-phenylbutyrate, Buphenyl, Sodium 4-phenylbutyrate, TriButyrate.
Abcam SU 5416 (Sema x anib), VEGFR-2 inhibitor, 50MG
MW 238.28 Da, Purity >99%. Selective VEGFR-2 inhibitor. Adenine mimetic. Inhibits endothelial cell proliferation. Inhibits angiogenesis and shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Abcam SC 221409, Cdk2 inhibitor, 5MG
MW 395.23 g/mol, Purity >97%. Potent, selective, ATP-competitive Cdk2 inhibitor (IC₅₀ = 60 nM). Cell-permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LY 294002 (DMSO solution), PI3-kinase inhibitor, 5MG-LQD
MW 307.3 Da, Purity >99%. A highly selective inhibitor of phosphatidylinositol 3-kinase (IC₅₀ = 1.4 μM). Selective over a range of other kinases including protein kinase C, protein kinase A, MAPK and PI4- kinase (IC₅₀ > 50 μM).
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Protease Inhibitor Cocktail | MFCD00677817 | 5 mL
Protease Inhibitor Cocktail | MFCD00677817 | 5 mL
Echelon Biosciences Research Labs XY-14 (Lipid Phosphate Phosphatase 1 Inhibitor) 0.5 mg
XY-14 is a competitive inhibitor of Lipid Phosphate Phosphatase 1 (LPP1) which is the major enzyme responsible for degrading lysophosphatidic acid (LPA) in platelets. XY-14 (10 M) inhibits LPP1 in human pulmonary artery endothelial cells, preventing the dephosphorylation of sphingosine 1-phosphate (S1P) to sphingosine. XY-14 is also reported to inhibit LPP2 & LPP3 This item is non returnable
Abcam Phosphatase Inhibitor Cocktail I, 1ML
Phosphatase Inhibitor Cocktail I (ab201112) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC DNA2 inhibitor C5 | 35973-25-2 | 98.5% | 10 MG
DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC50 of 20 μM. It inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. This product can be used in breast cancer and colorectal cancer research. It is for research use only and not sold to patients.
- Potent, competitive, and specific DNA2 nuclease inhibitor
- Inhibits nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2
- Useful in breast cancer and colorectal cancer research
- Exhibits strong synergistic effect in inhibiting MCF7 cell survival with MK4827
- Shows synthetic lethality with deficiencies in FEN1, EXO1, or MRE11 genes in mouse model
- IC50 of 20 μM for DNA2 nuclease
Abcam E-64d (Alo x istatin), cathepsin B and L inhibitor, 5MG
MW 342.4 Da, Purity >98%. Irreversible cell-permeable cathepsin B and L inhibitor. Inhibits calpain. Inhibits autophagy. Inhibits platelet proteolysis. Reduces brain amyloid-β levels. Shows neuroprotective effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical nDD8 InhIbItr M22 5mg
An inhibitor of NEDD8-activating enzyme; inhibits NEDDylation of UBC12 in a cell-free assay using recombinant human NAE; selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 cells; inhibits the growth of A549 cells (GI50 = 5.5 µM); inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model at 60 mg/kg